Gum Disease and Autism: More Vagus Nerve Proof Positive that Gut neurotransmitters get into the Brain!? YES

 Update:

The Spiritual Anatomy of Emotion: How Feelings Link the Brain, the Body, and the Sixth Sense

Ninety-five percent of the body’s serotonin is manufactured in the bowel from whence it travels to the head….Assisting in the dialog is the vagus nerve. The fact that 95 percent of its fibers run from the gut northwards….shouldn’t be surprising when one realizes that both the gut and the brain originate, during fetal development, from the
same clump of cells

.
p. 58,
Michael A. Jawer
 

 Ultrasonically-controlled stable and inertial microbubble oscillations (acoustic cavitation) exert forces that can, among others, activate cell’s mechanoreceptors[1], disrupt cellular and vascular membranes[2]–[4], accelerate the dissolution of blood clots[5], enhance thermal ablation[6], [7] and induce localized tissue erosion[8]. Harnessing these abilities holds great promise for therapy and diagnosis of central nervous system diseases and disorders[9], [10]. This measurement was found to correlate well with the level of blood-brain barrier permeabilization in experiments in non-human primates (NHP)[21]. In a separate study, we showed that the location of cavitation activity identified by the passive acoustic maps (PAMs) agreed with the location of the resulting MRI-evident blood-brain barrier permeabilization[31].

Military PDF - biological effects of acoustic cavitation

"When the eardrum is 'tightened' higher frequencies are absorbed and transmitted to the inner ear..." (Porges)

Focused Ultrasound-Induced Blood-Brain Barrier Opening - Nature

https://www.nature.com/articles/srep33264

by PC Chu - ‎2016 - ‎Cited by 10 - ‎Related articles

Sep 15, 2016 - Focused ultrasound (FUS) with microbubbles can temporally open the blood-brain barrier (BBB), and the cavitation activities of microbubbles play a key role in the BBB-opening process. Previous attempts used contrast-enhanced magnetic resonance imaging (CE-MRI) to correlate the

Void is YinYang: Gum Disease and Autism: More Vagus Nerve Proof Positive that Gut neurotransmitters get into the Brain!? YES

 I got my teeth cleaned today since I'll investigate a job tomorrow. So I actually showed the dental hygienist how I can "flex" my pineal gland causing my vagus nerve to pull up anaerobic bacteria and serotonin into my brain. haha. Hilarious! I had just bought this "Gum Dropps" organic essence oil to counteract the damage - but she freaked out a bit seeing my neck pulsating just from me "flexing" my pineal gland. I also shared some other energy secret science with her. She used an ultrasound cleaner on my teeth so that got me intrigued about if I would hear high pitch sound in my ears from demodulation.

Explanation of this image - further below - fascinating foreshadowing!

So this got me thinking - does standard mainstream science even know why there is a direct connection between the health of the gums and the health of the heart? I just assumed science knew that it is from the vagus nerve. So I realized that was another avenue for me to research the evidence that lower body neurohormones can get directly into the brain, bypassing the blood brain barrier, via the gut vagus nerve activation. Sure enough science does not know yet!!

 

One theory to explain it all - the vagus nerve:

It’s the Vagus Nerve Infection Hypothesis (VNIH) for chronic fatigue syndrome, and it could change how this disorder is viewed, researched and treated.
Created by Michael VanElzakker, a Tufts neuroscientist,  the VNIH proposes that nerve loving viruses trigger a difficult to detect  immune response which produces the fatigue and other symptoms present in chronic fatigue syndrome.

 What we’re looking for is increased cellular activity in the brain stem in a place called the nucleus of the solitary tract, which is where about 80 percent of these sensory vagus nerve fibers have their cell bodies.

This is essentially the place where the vagus nerve enters the brain. The idea is that if we can see extra signal there, there’s more activity there in Chronic Fatigue Syndrome patients than there is in healthy people, that would be evidence that there’s an exaggerated signal coming from the vagus nerve into the brain.

What we know is that when the vagus nerve detects cytokines in the body, it sends a signal to the brain, which then causes what we call a mirror response on the other side of the blood/brain barrier. Detection of cytokines in the blood of the periphery causes production of cytokines by these glial cells in the central nervous system. Part of that process is increasing this translocator protein.

 When the vagus nerve that comes from the brain to the organs is called the motor vagus or the efferent vagus, and that actually does control heart rate and that’s one of the main ways that we can measure vagal tone is what’s called heart rate variability and it’s the difference in heart rate between breaths. That’s very much a vagus nerve thing, which I think is also part of the reason that I think that the vagus nerve is involved in this condition is because there’s all these autonomic symptoms.

The link between gum health and heart disease - Delta Dental Insurance

https://www.deltadentalins.com/oral_health/heart.html

But even in non-smoking populations, researchers have found a strong correlation between the oral condition and heart disease. One hypothesis is that bacteria ...

 One hypothesis is that bacteria from the oral cavity spread throughout the body, worsening other inflammatory conditions, like heart disease, rheumatoid arthritis and type 2 diabetes.

So the idea is the bacteria goes from the mouth down to the heart. O.K. so the bacteria just gets into the bloodstream.   But from my experience it goes the other way also!

One of the most reliable ways to induce metabolic syndrome (and heart disease) is to disrupt the HPA-axis, be it by abusing cocaine, aquiring Cushing's disease, getting depressed, using corticosteroids or damaging your spine.

My dentist told me that some people suddenly develop severe periodontitis in times of grave psychosocial stress.

Just some thoughts.

Regards,

Melchior.

And someone follows up with more info:

 My dentist suggested vagus nerve stimulation as one of the courses of action to take in reducing stress and gum inflammation. (Some deep cleaning too). I used two very potent
vagus nerve stimulation techniques which are quite relaxing: The Dive Reflex and the Longevity Maneuver. My periodontal difficulties cleared up.

 Makes sense -

proof that that vagus nerve activation decreases inflammation, thereby decreasing septic bacterial growth

Lower estrogen levels affect bone metabolism and also affect the oral cavity, causing inflammatory changes in the body that can lead to gingivitis.

But then I found this Zinger!

Researchers have now observed gut bacteria consuming the brain chemical GABA. They found that a type of recently discovered gut bacteria, called KLE1738, can survive and reproduce only if it has GABA molecules to feed on. The researchers tried providing KLE1738 with other types of neurotransmitters but the bacteria couldn’t survive on anything but GABA. Without GABA, these bacteria die.

This is an important clue about how our gut bacteria influence our mood. “GABA acts by inhibiting signals from nerve cells, calming down the activity of the brain, so it’s surprising to learn that a gut bacterium needs it to grow and reproduce. Having abnormally low levels of GABA is linked to depression and mood disorders, and this finding adds to growing evidence that our gut bacteria may affect our brains.” (Coghlan, 2016)

An earlier experiment, in 2011, demonstrated that a different type of gut bacteria, Lactobacillus rhamnosus, dramatically altered GABA activity in the brains of mice as well as affected how well they responded to stress.

When the researchers surgically removed the vagus nerve, the communication pathway between the gut and the brain, the effect on the mice disappeared – more evidence on how gut bacteria influence the brain. (Coghlan, 2016)

The research team, led by Philip Strandwitz at Northeastern University in Boston, is now searching for other gut bacteria that consume or even produce GABA. They plan to test their effect on the brains and behavior of animals. Such work may eventually lead to new treatments for mood disorders like depression or anxiety.

“Due to this unique growth requirement, we provisionally name KLE1738 Evtepia gabavorous. Using growth of E. gabalyticus as an indicator, we then identified novel GABA producing bacteria from the gut microbiome. Reduced levels of GABA are associated with depression, and we found fewer GABA producers in a human cohort of depressed individuals. By modulating the level of GABA, microbial producers and consumers of this neurotransmitter may be influencing host behavior.” (Strandwitz et al, 2016)

So what this article is not saying is how the GABA gets from the gut into the brain!! It says all the other connections - bacteria in the gut can both produce GABA and eat GABA and depending on who has more of which bacteria then there is less or more GABA in a person's brain.

O.K.? So if that can happen for GABA then it should be also true for melatonin and serotonin - both of which are produced in massive amounts in the gut versus the brain. The gut produces 90% of the body's serotonin, the brain only 10% of the body's serotonin.

  We have recently demonstrated that 5-HT released from intestinal
enterochromaffin cells activates 5-HT3 receptors on vagal afferent fibres to mediate luminal
non-cholecystokinin-stimulated pancreatic secretion.

 Before it was assumed that the vagus nerve signal to the brain is adjusted via the amount of neurohormone in the gut - i.e.

Alterations in GABA receptor expression

Maybe they are just saying the same thing - that the vagus nerve signal changes the amount the brain produces - and no direct connection between the two. But we know that serotonin is also in the cerebrospinal fluid and the varying amounts of serotonin in the CSF affects the level of aggression or depression of a person. We know that brain serotonin goes into the CSF - and we know it's possible for the other way around to happen via the vagus nerve entrance into the brain.

But this research is all still very tentative. So what about GABA? Any more details discovered?

Breaking Down the Barriers - Finally new research admits stress, can break down the Blood-Brain-Barrier!

 This study strengthens the hypothesis that the BBB may also be vulnerable to changes in the gut microbiota.

About 90% of the fibers in the vagus nerve, the largest of the visceral nerves, carry information FROM the gut TO the brain – but not the other way around. (Hadhazy, 2010)

 O.K. So Dr. Mercola has an article on this:

The particular nerve of the parasympathetic chain that supplies the heart with nervous activity is called the vagus nerve; it slows and relaxes the heart, whereas the sympathetic branches accelerate and constrict the heart. I believe it can be shown that an imbalance in these two branches is responsible for the vast majority of heart disease.
Using the techniques of heart rate variability (HRV) monitoring, which gives a real time accurate depiction of autonomic nervous system status, researchers have shown in multiple studies ⁵ that patients with ischemic heart disease have on average a reduction of parasympathetic activity of over one-third.

So the dentist took my blood pressure and even though I have been eating a lot of bacon and sausage from my new half-hog and also drinking a lot of coffee - my blood pressure was 118/64

So I was very surprised but I know I also have a lot of parasympathetic nervous system activation from the qigong meditation. Sciencenews April 2016:

Gum disease opens up the body to a host of infections

Mouth microbes have been implicated in a variety of ills, from arthritis to Alzheimer’s

  Another type of oral bacteria, spirochetes called Treponema denticola, “are already known to enter the brain,” says neuroscientist Sim Singhrao of the University of Central Lancashire in England. Traveling along the nerves that connect to the jaw, “they are a bit like jellyfish, crawling up into neurological tissue.” Once nestled inside the brain, oral bacteria could trigger an inflammatory chain reaction that eventually destroys certain nerve cells and leads to Alzheimer’s disease, says StJohn Crean, Lancashire’s executive dean of the College of Clinical and Biomedical Sciences.

Wow spirochetes in the gums crawl up into the brain!!!

Crazy. So the feature cover story article of issue of Sciencenews is devoted to the Vagus Nerve connections....

Viva vagus: Wandering nerve could lead to range of therapies

Zapping the 10th cranial nerve may treat arthritis, heart failure, headaches and more

By

Sarah Schwartz

2:00pm, November 13, 2015

  Definitely - I zap my vagus nerve and I zap other peoples' vagus nerve. haha.

  Anchored in the brain stem, the vagus travels through the neck and into the chest, splitting into the left vagus and the right vagus. Each of these roads is composed of tens of thousands of nerve fibers that branch into the heart, lungs, stomach, pancreas and nearly every other organ in the abdomen. This broad meandering earned the nerve its name — vagus means “wandering” in Latin — and enables its diverse influence.

  Silencing norepinephrine-producing brain cells in rats erased the antidepressant effect of vagus nerve stimulation, scientists reported in the Journal of Psychiatric Research in September.

 O.K. so more proof vagus nerve activation increases the alterations of norepinephrine receptor expression right? or....

This [vagus] signal prompts other nerves to release norepinephrine, which makes immune T cells in the spleen release the chemical acetylcholine to depress inflammation via macrophages.

 Now that's interesting since in Taoist alchemy the spleen is the Earth Consciousness Intention as Yuan Qi source - and so increase the vagus to the brain, thereby increasing spleen acetylcholine anti-inflammation.

The researchers began cutting nerves one at a time to find the ones responsible for transmitting the anti-inflammatory signal from brain to body.
“When we cut the vagus nerve, which runs from the brain stem down to the spleen, the effect was gone,” says Tracey, president and CEO of the Feinstein Institute for Medical Research in Manhasset, N.Y. Later research indicated that stimulating undamaged vagus fibers also had anti-inflammatory effects in animals.
Vagus stimulation prompts release of acetylcholine, Tracey and colleagues reported in 2000. Acetylcholine, a neurotransmitter like norepinephrine, can prevent inflammation.

So vagus nerve stimulation treats arthritis. Amazing!!

  “From a scientific perspective, it’s an extremely exciting result,” says Tak, who is also a senior vice president at GlaxoSmithKline pharmaceuticals based in Stevenage, England.

 Yeah I bet.

What's hilarious is I read ScienceNews in order to reverse engineer their technology treatments via my own qigong meditation training.

So we know via the qigong science that qigong decreases serotonin in the blood but increases serotonin in the cerebrospinal fluid. Or maybe it was the other way around - but the idea I think - is that it takes it from the blood into the cerebrospinal fluid and then into the brain.

But in the ear, tiny fingers of the vagus’s fibers run close to the surface of the skin, primarily under the small flap of flesh, the tragus, that covers the ear’s opening. Studies have explored using stimulation of those fibers through the skin of the ear to treat heart failure, epilepsy and depression, as well as memory loss, headaches and even diabetes — a reflection of the [vagus] nerve’s control over a variety of hormones in addition to acetylcholine and norepinephrine.

 Right. So increased melatonin from vagus nerve stimulation via the ear! That indicates a direct vagus-pineal gland connection!

  electroCore device

A hand-held throat vagus nerve stimulator device!

That is what I do with my brain - make my throat pulsate! Hilarious a device now does the same.

I should post a youtube vid of my throat pulsating - I looked at it for the first time today while driving the car - in the rearview mirror. My whole throat was pulsating side to side - weird and hilarious!

SKIN DEEP Vagus nerve fibers run under the skin of the human ear. Long a target for acupuncture, this area is a target for external electrical stimulation (white dots).

  He compares vagus stimulation to flipping on a light switch in one room of a house and discovering that this endows other rooms in the house with magical powers.

Maybe he's been reading my blog! haha. Endrocrinology -

  The endothelial cells in the vasculature of the pineal are fenestrated so the organ is outwith the blood-brain barrier. Pinealocytes are specialized secretory cells controlled by the norepinephrine output from the sympathetic system.

Now hold on? The vagus nerve increases norepinephrine. So also vagus nerve increases melatonin. So.....

This occurs because the SCN receives a direct input from the retina (the retino-hypothalamic tract); it is the only part of the brain, apart from the visual cortex, to receive a direct input from the eye. Neurons from the SCN project to wide areas of the brain including the hypothalamic nuclei, the mid-brain raphe nucleus and the ventral lateral geniculate nucleus. It also projects indirectly to the pineal gland that, nestling between the rostral part of the cerebral hemispheres, secretes melatonin ( Box 7.33).

 So this must be - to reverse engineer this - how the qi-shen light is transmitted out of the pulsating eyeballs!

I was telling the dental hygienist about this. haha.

So - the pineal gland and eye balls are connected via the SCN.

That means there should be an SCN vagus nerve connection.

Vagus joins with other nerves.

Signals from the SCN are mainly transmitted by the vagal nerve because unilateral vagotomy completely abolished rhythms in mucin and PER2 protein levels in the (operated) ipsilateral side of the submucosal glands, but not in the (intact) contralateral side.

Bingo - the Eye-SCN-Vagus Nerve connection.

And now.....we have to go to an Autism study to find the goodies: pdf

trinitrobenzene sulfonic acid (TNBS).40 This is a standard
experimental model of inducing intestinal inflammation. In post-mortem brain sections, Dr.
Welch looked for evidence of immediate-early gene activation (Fos), which was increased in
certain areas of the brain that are known to be important in autism, such as the amygdala. This
was not seen in control animals that had saline exposure instead of TNBS. This same model has
been used to demonstrate other central nervous system changes in response to primary intestinal inflammation, including increased blood-brain barrier permeability and central autonomic activation that is independent of the vagus nerve.41 So in answer to the question: can a primary intestinal inflammation cause secondary brain activation? The answer is yes.

 Wow that is a direct hit! Finally. Citing what?

Welch MG, Welch-Horan TB, Anwar M, Anwar N, Ludwig RJ, Ruggiero DA. Brain effects of chronic IBD in areas abnormal in autism and treatment by single neuropeptides secretin and oxytocin. J Mol Neurosci.
2005;25(3):259-74.

The Seat of the Soul; The Origins of the Autism Epidemic. Andrew Wakefield

An important paper in this respect comes from Vargas and colleagues at Johns Hopkins.42
The study looked for evidence of immune activation in the brain and spinal fluid of patients with
autism and in controls. The principal cells of interest were microglia cells, which form part of the resident innate immune system of the brain. 

 So the implication is the reason we don't see any research on the connection of gut neurohormones getting into the brain directly is because that would prove how vaccines cause autism!!